In response to the Great Depression, the Mothers' Club Welfare Committee stepped up its efforts significantly throughout the 1930s. During this period, 2600 students registered for employment, with 154 being women. The club's members not only taught classes in cooking, gardening, and housecleaning but also actively promoted the hiring of these students within their community. The welfare committee also handled a substantial number of requests for essential items like clothing and textbooks.

In the early 1930s, before the Great Depression impacted Palo Alto, the Mothers' Club focused on fundraising to prepare for future student needs. Their 1931 spring event, featuring tea, card games, fortune-telling, and music, charged only 50 cents per ticket and drew a large crowd, with over 1,000 guests in attendance.

Records from the early 1930s reveal that the Mothers' Club covered the expenses for a nursing home for a student suffering from tuberculosis. They also provided financial support for books and tuition to a medical student who had forfeited all his savings due to a bank failure.